Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases - INRA - Institut national de la recherche agronomique
Article Dans Une Revue EMBO Molecular Medicine Année : 2022

Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases

Résumé

Human secretory immunoglobulins (SIg) A1 and SIgA2 guide mucosal responses toward tolerance or inflammation, notably through reverse-transcytosis, the apical-to-basal transport of IgA2 immune complexes via M cells of gut Peyer's patches. As such, the maintenance of a diverse gut microbiota requires broad affinity IgA and glycan-glycan interaction. Here, we asked whether IgA1 and IgA2-microbiota interactions might be involved in dysbiosis induction during inflammatory bowel diseases. Using stool HPLCpurified IgA, we show that reverse-transcytosis is abrogated in ulcerative colitis (UC) while it is extended to IgA1 in Crohn's disease (CD). 16S RNA sequencing of IgA-bound microbiota in CD and UC showed distinct IgA1-and IgA2-associated microbiota; the IgA1 + fraction of CD microbiota was notably enriched in beneficial commensals. These features were associated with increased IgA anti-glycan reactivity in CD and an opposite loss of reactivity in UC. Our results highlight previously unknown pathogenic properties of IgA in IBD that could support dysbiosis.
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hal-04871841 , version 1 (07-01-2025)

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Eva Michaud, Louis Waeckel, Rémi Gayet, Roman Goguyer‐deschaumes, Blandine Chanut, et al.. Alteration of microbiota antibody‐mediated immune selection contributes to dysbiosis in inflammatory bowel diseases. EMBO Molecular Medicine, 2022, 14 (8), ⟨10.15252/emmm.202115386⟩. ⟨hal-04871841⟩
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